Interpretable Machine Learning for Antepartum Prediction of Pregnancy-Associated Thrombotic Microangiopathy Using Routine Longitudinal Laboratory Data

Background: Pregnancy-associated thrombotic microangiopathy (P-TMA) is rare but life-threatening. Early risk prediction before overt clinical presentation remains challenging, as the associated laboratory abnormalities are subtle, multidimensional, and frequently masked by common physiological changes such as gestational thrombocytopenia and pregnancy-related proteinuria, thus overlapping heavily with benign obstetric and renal conditions. This complexity is poorly captured by univariate or rule-based approaches; however, it is addressable by machine learning, which can extract latent, time-dependent risk signatures from longitudinal clinical tests. Methods: This retrospective study included 300 pregnancies comprising 142 P-TMA cases and 158 controls. After exclusion of identifiers and non-informative variables, 146 longitudinal laboratory predictors were retained. Participants were divided into a training cohort (80%) and a held-out test cohort (20%) using stratified sampling. Five algorithms were evaluated: logistic regression, support vector machine with radial basis function kernel, random forest, extra trees, and gradient boosting. The final model was selected by mean cross-validated AUROC, refitted on the full training cohort, and evaluated once in the held-out test cohort. Interpretability analyses examined global feature importance and distributional patterns of leading predictors. Results: Gradient boosting was prespecified by cross-validation in the training cohort. The model achieved an AUROC of 0.872 (95% CI: 0.769-0.952) and an AUPRC of 0.883 (95% CI: 0.780-0.959) in a held-out test cohort, with sensitivity of 0.750 and specificity of 0.812. Conclusions: Longitudinal clinical laboratory tests obtained during routine care contained informative and clinically plausible signals for P-TMA risk. Notably, cystatin C at week 6 showed promise as an early monitoring indicator.

HLS-Seek: QoR-Aware Code Generation for High-Level Synthesis via Proxy Comparative Reward Reinforcement Learning

High-Level Synthesis (HLS) compiles algorithmic C/C++ descriptions into hardware, with Quality of Results (QoR) -- latency and resource utilization -- critically governed by pragma configurations and code structure. Existing LLM-based HLS approaches train for functional correctness but ignore QoR entirely. We observe that reinforcement learning (RL) for HLS does not require absolute synthesis results -- only relative comparisons between candidates. Based on this insight, we propose \textbf{HLS-Seek}, a QoR-aware NL-to-HLS framework that replaces expensive synthesis-in-the-loop RL with a comparative proxy reward model achieving 99.53\% Pareto-dominance accuracy. To prevent reward hacking, we introduce \textit{uncertainty-aware Monte Carlo (MC) dropout switching} that selectively invokes real Vitis HLS synthesis for low-confidence candidates and online updates the proxy, creating a self-improving reward system. HLS-Seek achieves 81.5\% syntax correctness pass@1 and 81.4\% Func@5 on HLS-eval with only 7B parameters, surpassing GPT-5.1 and other frontier models while achieving 8.5$\times$ faster training than real-reward RL. On QoR evaluation, HLS-Seek achieves the lowest latency on 16/30 kernels and Pareto-dominates HLS-specific baselines on 9 kernels.

CCL-D: A High-Precision Diagnostic System for Slow and Hang Anomalies in Large-Scale Model Training

As training scales grow, collective communication libraries (CCL) increasingly face anomalies arising from complex interactions among hardware, software, and environmental factors. These anomalies typically manifest as slow/hang communication, the most frequent and time-consuming category to diagnose. However, traditional diagnostic methods remain inaccurate and inefficient, frequently requiring hours or even days for root cause analysis. To address this, we propose CCL-D, a high-precision diagnostic system designed to detect and locate slow/hang anomalies in large-scale distributed training. CCL-D integrates a rank-level real-time probe with an intelligent decision analyzer. The probe measures cross-layer anomaly metrics using a lightweight distributed tracing framework to monitor communication traffic. The analyzer performs automated anomaly detection and root-cause location, precisely identifying the faulty GPU rank. Deployed on a 4,000-GPU cluster over one year, CCL-D achieved near-complete coverage of known slow/hang anomalies and pinpointed affected ranks within 6 minutes-substantially outperforming existing solutions.

Khala: Scaling Acoustic Token Language Models Toward High-Fidelity Music Generation

A common design pattern in high-quality music generation is to handle structure and fidelity in different representation spaces: a generator first models high-level structure, followed by diffusion-based or neural decoding stages that reconstruct fine details. In this work, we explore an alternative view: both may be progressively modeled within a single deep acoustic-token hierarchy. To study this, we build a 64-layer residual vector quantization (RVQ) acoustic representation and propose a two-stage coarse-to-fine generation framework. A backbone model first generates coarse acoustic tokens for the full track, and a super-resolution model then completes finer tokens within the same acoustic token space. The super-resolution stage works at full-track scale and refines tokens layer by layer while running in parallel over time, leading to a fixed 62-step inference process. To jointly improve lyric alignment and fine-detail reconstruction, we further introduce hybrid-attention training: the alignment objective uses causal attention, while layer-wise refinement uses full attention. A key finding is that text--vocal alignment can emerge within pure acoustic-token language modeling, without requiring a separate semantic token stage. Moreover, initializing the super-resolution model from the trained backbone significantly improves convergence and final quality. Taken together, our results suggest that high-quality music generation can be effectively pursued without separating structure and fidelity into heterogeneous representation spaces. Instead, both can be progressively modeled within a unified acoustic-token hierarchy, pointing toward a simpler and more unified path to high-quality music generation.

SymphonyGen: 3D Hierarchical Orchestral Generation with Controllable Harmony Skeleton

Generating symphonic music requires simultaneously managing high-level structural form and dense, multi-track orchestration. Existing symbolic models often struggle with a "complexity-control imbalance", in which scaling bottlenecks limit long-term granular steerability. We present SymphonyGen, a 3D hierarchical framework for contemporary cinematic orchestration. SymphonyGen employs a cascading decoder architecture that decomposes the Bar, Track, and Event axes, improving computational efficiency and scalability over conventional 1D or 2D models. We introduce "short-score" conditioning via a beat-quantized multi-voice harmony skeleton, enabling outline control while preserving textural diversity. The model is further refined using Group Relative Policy Optimization (GRPO) with a cross-modal audio-perceptual reward, aligning symbolic output with modern acoustic expectations. Additionally, we implement a dissonance-averse sampling algorithm to suppress unintended tonal clashes during inference. Objective evaluations show that both reinforcement learning and dissonance-averse sampling effectively enhance harmonic cleanliness while maintaining melodic expression. Subjective evaluations demonstrate that SymphonyGen outperforms baselines in musicality and preference for orchestral music generation. Demo page: https://symphonygen.github.io/

Laplace-Bridged Randomized Smoothing for Fast Certified Robustness

Randomized Smoothing (RS) offers formal $\ell_2$ guarantees for arbitrary base classifiers but faces two key practical bottlenecks: (i) it often relies on noise-augmented training to achieve nontrivial certificates, which increases training cost, can reduce clean accuracy, and weakens RS as a genuinely post-hoc defense; and (ii) certification is computationally expensive, typically requiring tens of thousands of noisy forward passes per input, which hinders deployment, especially on resource-constrained edge devices. To address both limitations, we propose Laplace-Bridged Smoothing (LBS), an analytic reformulation of RS that replaces high-dimensional input-space Monte Carlo (MC) sampling with efficient computations in a low-dimensional probability space. LBS preserves formal robustness guarantees without requiring noise-augmented training while substantially reducing certification burden. On CIFAR-10 and ImageNet, LBS attains stronger certified robustness than RS and reduces per-sample certification cost by nearly an order of magnitude. Notably, on NVIDIA Jetson Orin Nano and Raspberry Pi 4, LBS achieves speedups of up to $494\times$, enabling practical certified deployment on real-world edge devices. Finally, we provide theoretical justification for the analytic formulation and certificate validity of LBS.

Vision-Based End-to-End Learning for UAV Traversal of Irregular Gaps via Differentiable Simulation

-Navigation through narrow and irregular gaps is an essential skill in autonomous drones for applications such as inspection, search-and-rescue, and disaster response. However, traditional planning and control methods rely on explicit gap extraction and measurement, while recent end-to-end approaches often assume regularly shaped gaps, leading to poor generalization and limited practicality. In this work, we present a fully vision-based, end-to-end framework that maps depth images directly to control commands, enabling drones to traverse complex gaps within unseen environments. Operating in the Special Euclidean group SE(3), where position and orientation are tightly coupled, the framework leverages differentiable simulation, a Stop-Gradient operator, and a Bimodal Initialization Distribution to achieve stable traversal through consecutive gaps. Two auxiliary prediction modules-a gap-crossing success classifier and a traversability predictor-further enhance continuous navigation and safety. Extensive simulation and real-world experiments demonstrate the approach's effectiveness, generalization capability, and practical robustness.

QuadAgent: A Responsive Agent System for Vision-Language Guided Quadrotor Agile Flight

We present QuadAgent, a training-free agent system for agile quadrotor flight guided by vision-language inputs. Unlike prior end-to-end or serial agent approaches, QuadAgent decouples high-level reasoning from low-level control using an asynchronous multi-agent architecture: Foreground Workflow Agents handle active tasks and user commands, while Background Agents perform look-ahead reasoning. The system maintains scene memory via the Impression Graph, a lightweight topological map built from sparse keyframes, and ensures safe flight with a vision-based obstacle avoidance network. Simulation results show that QuadAgent outperforms baseline methods in efficiency and responsiveness. Real-world experiments demonstrate that it can interpret complex instructions, reason about its surroundings, and navigate cluttered indoor spaces at speeds up to 5 m/s.

Vector Field Augmented Differentiable Policy Learning for Vision-Based Drone Racing

Autonomous drone racing in complex environments requires agile, high-speed flight while maintaining reliable obstacle avoidance. Differentiable-physics-based policy learning has recently demonstrated high sample efficiency and remarkable performance across various tasks, including agile drone flight and quadruped locomotion. However, applying such methods to drone racing remains difficult, as key objective like gate traversal are inherently hard to express as smooth, differentiable losses. To address these challenges, we propose DiffRacing, a novel vector field-augmented differentiable policy learning framework. DiffRacing integrates differentiable losses and vector fields into the training process to provide continuous and stable gradient signals, balancing obstacle avoidance and high-speed gate traversal. In addition, a differentiable Delta Action Model compensates for dynamics mismatch, enabling efficient sim-to-real transfer without explicit system identification. Extensive simulation and real-world experiments demonstrate that DiffRacing achieves superior sample efficiency, faster convergence, and robust flight performance, thereby demonstrating that vector fields can augment traditional gradient-based policy learning with a task-specific geometric prior.

AI-IO: An Aerodynamics-Inspired Real-Time Inertial Odometry for Quadrotors

Inertial Odometry (IO) has gained attention in quadrotor applications due to its sole reliance on inertial measurement units (IMUs), attributed to its lightweight design, low cost, and robust performance across diverse environments. However, most existing learning-based inertial odometry systems for quadrotors either use only IMU data or include additional dynamics-related inputs such as thrust, but still lack a principled formulation of the underlying physical model to be learned. This lack of interpretability hampers the model's ability to generalize and often limits its accuracy. In this work, we approach the inertial odometry learning problem from a different perspective. Inspired by the aerodynamics model and IMU measurement model, we identify the key physical quantity--rotor speed measurements required for inertial odometry and design a transformer-based inertial odometry. By incorporating rotor speed measurements, the proposed model improves velocity prediction accuracy by 36.9%. Furthermore, the transformer architecture more effectively exploits temporal dependencies for denoising and aerodynamics modeling, yielding an additional 22.4% accuracy gain over previous results. To support evaluation, we also provide a real-world quadrotor flight dataset capturing IMU measurements and rotor speed for high-speed motion. Finally, combined with an uncertainty-aware extended Kalman filter (EKF), our framework is validated across multiple datasets and real-time systems, demonstrating superior accuracy, generalization, and real-time performance. We share the code and data to promote further research (https://github.com/SJTU-ViSYS-team/AI-IO).